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KMID : 0357119940160010001
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Korean Journal of Immunology
1994 Volume.16 No. 1 p.1 ~ p.8
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The Effect of Calcium Channel Blocker and Calmodulin Inhibitor on the Activation of the Macrophage
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Abstract
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Toinvestigate the role of calcium in the biochemical process by which macrophages become activated to the tumoricidal state, the effect of calcim channel blokers and calmodulin antagonists on the acquisition of tumoricidal properties of
macrophage
activated by a number of different agent was examined.
Activation of thioglycollate-stimulated C57BL/6J mouse peritoneal macrophages by interferon-γ(FN-γ) plus lipopolysaccharide(LPS) or the calcium ionophore A 23187. Was inhibited in a dose dependent fashion by the calcium channel blokers.
Nifedipine and
verapamil. These agents block the influx of 45Ca2+ into macrophages activated IFN-γ plus LPS. Macrophage activation was also inhibited by chlorprom azine, W-7, and calmibazolium at concentrations known to perturb calmodulin function. The data
suggest
that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane
calcium fluxes and/or inhibit calmodulin function.
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KEYWORD
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